Genomic Contributors to Sex Differences in Human Biology

The San Roman Lab uses an integrated approach encompassing human cell culture models, functional genomics, epigenetics, and bioinformatics, to uncover how variation in sex chromosome copy number influences human health and disease. The lab is currently exploring the molecular roles of sex-linked gene regulatory factors, investigating the direct effects of sex chromosome constitution in multiple contexts, including infection, tissue homeostasis, and cancer pathogenesis, and applying epigenetic editing approaches to restore euploid gene expression in sex chromosome aneuploidy syndromes.